https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 MicroRNA expression is altered in an ovalbumin-induced asthma model and targeting miR-155 with antagomirs reveals cellular specificity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22109 Wed 11 Apr 2018 16:41:47 AEST ]]> Expression profiling of differentiating eosinophils in bone marrow cultures predicts functional links between microRNAs and their target mRNAs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16812 Wed 11 Apr 2018 12:55:19 AEST ]]> Identification of the microRNA networks contributing to macrophage differentiation and function https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28036 Wed 11 Apr 2018 12:47:04 AEST ]]> Identification of MicroRNAs regulating the developmental pathways of bone marrow derived mast cells https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20638 Wed 11 Apr 2018 09:20:21 AEST ]]> Bromodomain and extra terminal (BET) inhibitor suppresses macrophage-driven steroid-resistant exacerbations of airway hyper-responsiveness and inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30136 Wed 10 Nov 2021 15:14:29 AEDT ]]> MicroRNA-487b is a negative regulator of macrophage activation by targeting IL-33 production https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30084 Thu 03 Feb 2022 12:18:07 AEDT ]]> A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18118 dGag197–205 challenge compared to rDNA poxvirus prime-boost strategy. Our findings further substantiate the importance of vector selection/combination, order and route of delivery when designing effective vaccines for HIV-1.]]> Sat 24 Mar 2018 08:04:36 AEDT ]]> MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22280 in silico and confirmed in luciferase reporter assays. miR-9 function was inhibited with sequence-specific antagomirs. The efficacy of DEX was assessed by quantifying glucocorticoid receptor (GR) cellular localization, protein phosphatase 2A (PP2A) activity, and AHR. Results: Exposure of pulmonary macrophages to IFN-γ/LPS synergistically induced miR-9 expression; reduced levels of its target transcript, protein phosphatase 2 regulatory subunit B (B56) δ isoform; attenuated PP2A activity; and inhibited DEX-induced GR nuclear translocation. Inhibition of miR-9 increased both PP2A activity and GR nuclear translocation in macrophages and restored steroid sensitivity in multiple models of steroid-resistant AHR. Pharmacologic activation of PP2A restored DEX efficacy and inhibited AHR. MiR-9 expression was increased in sputum of patients with neutrophilic but not those with eosinophilic asthma. Conclusion: MiR-9 regulates GR signaling and steroid-resistant AHR. Targeting miR-9 function might be a novel approach for the treatment of steroid-resistant asthma.]]> Sat 24 Mar 2018 07:17:42 AEDT ]]> TNF-α and macrophages are critical for respiratory syncytial virus-induced exacerbations in a mouse model of allergic airways disease https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24758 Sat 24 Mar 2018 07:14:04 AEDT ]]> Identification of IFN-γ and IL-27 as critical regulators of respiratory syncytial virus-induced exacerbation of allergic airways disease in a mouse model https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33087 Fri 24 Aug 2018 16:25:53 AEST ]]> GSTO1-1 is an upstream suppressor of M2 macrophage skewing and HIF-1α-induced eosinophilic airway inflammation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40046 Fri 15 Jul 2022 10:05:42 AEST ]]> Lipopolysaccharide induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41761 Fri 12 Aug 2022 11:42:33 AEST ]]> IL-17A is a common and critical driver of impaired lung function and immunopathology induced by influenza virus, rhinovirus and respiratory syncytial virus https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49776 Fri 02 Jun 2023 17:29:57 AEST ]]>